NFL Week 10 2025 - Weekly Picks Against the Spread and Straight up


We’ve reached the midpoint of the 2025 NFL season!

After a week nine full of upsets and close games, the nightmare of unending blowouts in week eight is firmly behind us. As the season swings into the second half, week ten promises some great matchups.

Thursday night kicks off the week with the AFC West leading Denver Broncos facing off with Pete Carroll and the Las Vegas Raiders. Plan your brunch, as the 9:30AM International game at Olympiastadion in Berlin features the AFC leading Indianapolis Colts taking on the Atlanta Falcons.

Carolina could go to 6-4 hosting New Orleans, the Bears could get to 6-3 with a winnable game against Jaxson Dart and the Giants. In the AFC East, the Bills take on the dreadful Dolphins while the one-win Jets have a winnable game against the hot-mess Browns. 

New England takes on the NFC South leading Bucs and the Ravens and Vikings face-off as both preseason favorites teeter on the edge of missing the playoffs. The early window finished up with Jacksonville facing Houston in a big AFC South matchup.

In the late window, the NFC West has the Cardinals visiting the Seahawks and the Rams visiting the 49ers. The Lions visit the Commanders in a must-win game for Washington. Sunday Night Football features two AFC titans as the Steelers and Aaron Rodgers visit LA to take on Justin Herbert and the Chargers.

The week wraps up with a great ABC/ESPN Monday Night Football game with the world champion Eagles going to Green Bay to face off with the Packers in a potential NFC Championship game preview. 

Each week during the season, I make my picks with my buddy David on his SportsKrunch with DKrom podcast as we’ve done regularly for the past five years (and pre-pandemic as well). 

Check out the episode as we recapped week nine, graded the biggest of the trades, gave out the midseason awards, and all the predictions and prognostications--it is available here.

Please give a listen each week on your preferred podcast provider. All back episodes are available here at Apple podcasts.

Last Week: Straight up: 9-5; Against the Spread: 6-8

Season Totals: Straight up: 85-49-1; Against the Spread: 66-69

Lock of the Week: 6-3

Upset Special: 3-6

Now, on to the week ten picks!

2025 NFL Week 10 Picks

THURSDAY NIGHT FOOTBALL

RAIDERS 3 @ BRONCOS 17

Spread: Broncos -8.5: Broncos

Moneyline: Broncos -455, Raiders +350: Broncos

 

(edit: Broncos won 10-7. Another Divisional game and the underdog covers. I should know better at this point. Dismal performance from the Broncos’ offense. At least I nailed the under!)


INTERNATIONAL GAME

FALCONS 16 @ COLTS 30

Spread: Colts -6.5: Colts

Moneyline: Colts -325, Falcons +260: Colts

 

SUNDAY 1:00PM

PATRIOTS 20 @ BUCCANEERS 24

Spread: Buccaneers -2.5: Bucs

Moneyline: Buccaneers -135, Patriots +114: Bucs

 

BILLS 31 @ DOLPHINS 11 (LOCK OF THE WEEK)

Spread: Bills -9.5: Bills

Moneyline: Bills -470, Dolphins +360: Bills

 

RAVENS 26 @ VIKINGS 23

Spread: Ravens -4.5: Vikings

Moneyline: Ravens -192, Vikings +160: Vikings

 

JAGUARS 18 @ TEXANS 16

Spread: Texans -1.5: Jaguars

Moneyline: Texans -125, Jaguars +105: Jaguars

 

GIANTS 20 @ BEARS 22

Spread: Bears -3.5: Giants

Moneyline: Bears -185, Giants +154: Bears

 

BROWNS 9 @ JETS 6

Spread: Jets -1.5: Browns

Moneyline: Jets -125, Browns +105: Browns

 

SAINTS 17 @ PANTHERS 27

Spread: Panthers -5.5: Panthers

Moneyline: Panthers -250, Saints +205: Panthers

 

4:05/4:25PM:

CARDINALS 20 @ SEAHAWKS 26

Spread: Seahawks -6.5: Cardinals

Moneyline: Seahawks -345, Cardinals +275: Seahawks

 

LIONS 31 @ COMMANDERS 13

Spread: Lions -8.5: Lions

Moneyline: Lions -455, Commanders +350: Lions

 

RAMS 25 @ 49ERS 28 (Upset Special)

Spread: Rams -3.5: 49ers

Moneyline: Rams -175, 49ers +145: 49ers


SUNDAY NIGHT FOOTBALL:

STEELERS 18 @ CHARGERS 22

Spread: Chargers -3: Chargers

Moneyline: Chargers -175, Steelers +145: Chargers

 

MONDAY NIGHT FOOTBALL:

EAGLES 22 @ PACKERS 26

Spread: Packers -2.5: Packers

Moneyline: Packers -142, Eagles +120: Packers


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