NFL Week 2 2025 - Weekly Picks Against the Spread and Straight up

The NFL didn’t disappoint with an engaging series of games for Kickoff Weekend, particularly the prime time national games. 




Week two has another interesting slate of games kicked off by one of the best games of the week on Thursday night. 


That’s followed up by nine games in the 1:00 PM Eastern time block and then three games in the 4:05/4:25PM Eastern time block. As usual, Sunday Night Football has week one here J.J. McCarthy leading the Minnesota Vikings with their fired up crowd against exciting young quarterback Michael Penix and the Atlanta Falcons.


It all wraps up for week two with two Monday Night Football games with Tampa Bay against Houston in the early game at 7:00PM Eastern and the Chargers and Raiders facing off in the 10:00PM window.


Each week during the season, I will be making my picks with my buddy David on his SportsKrunch with DKrom podcast as we’ve done regularly for the past five years (and pre-pandemic as well). This weeks’ episode is available here.


Please give a listen each week on your preferred podcast provider. All back episodes are available here at Apple podcasts.


Last Week: Straight up: 10-6; Against the Spread: 6-10

Season Totals: Straight up: 10-6; Against the Spread: 6-10


Now, on to the week two picks!


Thursday Night Football:

Washington 20 @ Green Bay (-3) 27

Against the Spread: Green Bay

Straight up: Green Bay


Edit: This was a good way to start the week. Win straight up and vs the spread.

 

Broncos (-2.5) 22 at Colts 19

Against the Spread: Broncos

Straight up: Broncos


Jaguars 20 at Bengals (-3.5) 28

Against the Spread: Bengals

Straight up: Bengals


Giants 19 at Cowboys (-5.5) 22

Against the Spread: Giants

Straight up: Cowboys


Bears 26 at Lions (-6) 30

Against the Spread: Bears

Straight up: Lions


Bills (-6.5) 30 at Jets 13

Against the Spread: Bills

Straight up: Bills


Patriots 24 at Dolphins 25 (-1.5)

Against the Spread: Patriots

Straight up: Dolphins


Browns 17 at Ravens 24 (-11.5)

Against the Spread: Browns

Straight up: Ravens


Seahawks 23 at Steelers (-3) 18

Against the Spread: Seahawks

Straight up: Seahawks


Rams (-5.5) 27 at Titans 20

Against the Spread: Rams

Straight up: Rams


49ers (-3) 20 at Saints 18

Against the Spread: Saints

Straight up: 49ers


Panthers 17 at Cardinals (-6.5) 27

Against the Spread: Cardinals

Straight up: Cardinals


Eagles (-1.5) 35 at Chiefs 31

Against the Spread: Eagles

Straight up: Eagles


Sunday Night:


Falcons 29 at Vikings (-3.5) 26 (UPSET SPECIAL)

Against the Spread: Falcons

Straight up: Falcons


Monday Night:

 

Bucs 20 at Texans (-2.5) 19

Against the Spread: Texans

Straight up: Bucs


Chargers (-3) 38 at Raiders 17 (LOCK OF THE WEEK)

Against the Spread: Chargers

Straight up: Chargers


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