NFL Week 5 2025 - Weekly Picks Against the Spread and Straight up

The NFL is just now getting to the quarter pole and only two undefeated teams remain as the World Champion Philadelphia Eagles and Buffalo Bills look to remain in the winning column in week five.

Week five has a slew of interesting match-ups kicked off by an early battle for supremacy in the NFC West on Amazon’s Thursday Night Football. 


That’s followed up by a London game for Breakfast and Football Sunday morning. As it is the first week with byes, four teams are not playing this week. There are six games in the 1:00 PM Eastern time block and then four games in the 4:05/4:25PM Eastern time block. Sunday Night Football on NBC features the Patriots and the Bills in an AFC East match-up. 


It all wraps up for week five with a Monday Night Football game with Patrick Mahomes and the Kansas City Chiefs in Duuuuvalllll to take on a rejuvenated Jacksonville Jaguars team that is 3-1 and tied for first in the AFC South.


Each week during the season, I make my picks with my buddy David on his SportsKrunch with DKrom podcast as we’ve done regularly for the past five years (and pre-pandemic as well). I was out on vacation but still sent my picks in to David from the Vanilla Gorilla cafe near Times Square in New York City where I enjoyed an amazing cappuccino and they also were nice enough to whip me up a delicious London Fog while we waited for the train home.


Sadly, I wasn’t able to record this weeks’ episode but I was lucky that Carl Dumler was available to more than ably fill in. Check out the episode as it is available here.


Please give a listen each week on your preferred podcast provider. All back episodes are available here at Apple podcasts.


Last Week: Straight up: 9-6-1; Against the Spread: 7-9

Season Totals: Straight up: 42-21-1; Against the Spread: 32-32

Lock of the Week: 3-1

Upset Special: 1-3


Now, on to the week five picks!


THURSDAY NIGHT FOOTBALL 8:15PM

49ERS @ RAMS

Spread: Rams -5.5: 49ers
Moneyline: Rams -258, 49ers +210: Rams

(edit: Hit on the 49ers covering but really did not expect the Rams to drop a game to Mac Jones)


SUNDAY MORNING 9:30AM

VIKINGS @ BROWNS

Spread: Vikings -4.5: Vikings
Moneyline: Vikings -198, Browns +164: Vikings

SUNDAY AFTERNOON 1:00PM

BRONCOS @ EAGLES

Spread: Eagles -4.5: Broncos
Moneyline: Eagles -218, Broncos +180: Eagles


TEXANS @ RAVENS

Spread: Ravens -3.5: Texans
Moneyline: Ravens -185, Texans +154: Texans


RAIDERS @ COLTS

Spread: Colts -6.5: Raiders
Moneyline: Colts -305, Raiders +245: Colts


COWBOYS @ JETS

Spread: Cowboys -3: Cowboys
Moneyline: Cowboys -145, Jets +130: Cowboys


DOLPHINS @ PANTHERS

Spread: Panthers -1.5: Panthers
Moneyline: Dolphins -102, Panthers -118: Panthers


GIANTS @ SAINTS

Spread: Giants -1.5: Giants
Moneyline: Giants +102, Saints -122: Giants 


SUNDAY AFTERNOON 4:05/4:25PM:

BUCCANEERS @ SEAHAWKS

Spread: Seahawks -3: Seahawks
Moneyline: Seahawks -162, Buccaneers +136: Seahawks


TITANS @ CARDINALS

Spread: Cardinals -8.5: Cardinals (Lock of the Week)
Moneyline: Cardinals -455, +350: Cardinals


LIONS @ BENGALS

Spread: Lions -10: Lions
Moneyline: Lions -520, Bengals +39: Lions


COMMANDERS @ CHARGERS

Spread: Chargers -2.5: Chargers
Moneyline: Chargers -142, Commanders +120: Chargers 


SUNDAY NIGHT FOOTBALL 8:20PM:

PATRIOTS @ BILLS

Spread: Bills -8.5: Patriots
Moneyline: Bills -410, Patriots +320: Bills

(Check out W2W4 (What to Watch For) for an in-depth and complete game preview)


MONDAY NIGHT FOOTBALL 8:15PM:

CHIEFS @ JAGUARS

Spread: Chiefs -3.5: Jaguars (Upset Special)
Moneyline: Chiefs -192, Jaguars +160: Jaguars 



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